Block-US it’s a Inno-Sol patented general solution to the problem of side-leakage and modes conversion of ultrasound propagating waves in the commercially available well-plates. It works using a proprietary polymer to fill all inter-well spaces and is applicable to all commercial disposable well-plates for cell culture. The polymer absorbs the transverse waves leaking-through and effectively dampens the lateral diffusion, when the plate is sonicated from bottom with ultrasonic waves. US impacting on the bottom well common lamina generates conversion mode phenomena which diffuses waves traveling both within the solid material thickness and other at its surface interface thus impacting also the inner solution within the well. Further benefit of using Block-US is the effective dampening of the bottom well surface waves traveling along the surface of common lamina material.